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Clenbuterol plus acivicin decrease tumor growth and increase muscle mass in rats maintained on total parenteral

W T Chance1, L Cao, F S Zhang

  • 1Department of Surgery, University of Cincinnati Medical Center, Ohio 45267.

American Journal of Surgery
|January 1, 1991
PubMed
Summary

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Supplemental nutrition for tumor-bearing rats using acivicin and clenbuterol arrested tumor growth and reduced cachexia. This study shows controlling tumor growth and muscle wasting during total parenteral nutrition (TPN) is possible.

Area of Science:

  • Oncology
  • Metabolic Research
  • Nutritional Science

Background:

  • Tumor-bearing organisms face challenges with supplemental nutrition, including controlling tumor growth and mitigating cachexia.
  • Cachexia, characterized by lean body tissue depletion, is a significant concern in neoplastic diseases.

Purpose of the Study:

  • To investigate methods for controlling tumor growth and reducing cachexia in tumor-bearing rats receiving total parenteral nutrition (TPN).
  • To evaluate the combined effects of acivicin and clenbuterol on tumor progression and host metabolism.

Main Methods:

  • Rats with methylcholanthrene-induced sarcomas were administered TPN for 10-12 days, starting 23 days post-inoculation.
  • A subset of rats received combined treatment with acivicin (glutamine antimetabolite) and clenbuterol (beta 2-adrenergic agonist).

Related Experiment Videos

  • Measurements included tumor growth, skeletal muscle mass and protein, gut mass, plasma lipid levels, resting energy expenditure, and cardiac mass.

    • Main Results:

    • Combined acivicin and clenbuterol treatment arrested tumor growth.
    • Skeletal muscle mass and protein content, as well as gut mass, were significantly increased.
    • Total plasma lipid levels decreased, while resting energy expenditure and cardiac mass increased with TPN and further with the combined treatment.

    Conclusions:

    • Tumor growth and associated muscle wasting can be effectively managed during TPN in tumor-bearing animals.
    • The findings suggest that cachectic depletion of lean body tissue may not be an unavoidable consequence of neoplastic disease.
    • This therapeutic approach holds potential for improving nutritional support and managing body composition in cancer patients.