Assessment and treatment of stroke in children

Lori C Jordan1

  • 1Lori C. Jordan, MD Johns Hopkins University School of Medicine, 200 North Wolfe Street, Suite 2158,Baltimore, MD 21287, USA. ljordan2@jhmi.edu.

Insights

Pediatric stroke is a significant cause of childhood disability, affecting 2-3 per 100,000 children. Urgent evaluation and targeted treatment are crucial for improving outcomes in pediatric stroke patients.

Area of Science:

  • Neurology
  • Pediatrics
  • Public Health

Background:

  • Pediatric stroke is underrecognized despite being a major cause of childhood disability.
  • Ischemic and hemorrhagic strokes occur with similar frequency in children.
  • Limited research exists on evaluating and treating pediatric stroke, except in sickle cell disease.

Purpose of the Study:

  • To highlight the significance of pediatric stroke as a cause of disability.
  • To emphasize the need for urgent and thorough evaluation of children with stroke.
  • To discuss current understanding and gaps in treatment guidelines for pediatric stroke.

Main Methods:

  • Review of existing literature on pediatric stroke.
  • Analysis of incidence and types of stroke in children.
  • Comparison with adult stroke management and guidelines.

Main Results:

  • Pediatric stroke incidence is 2-3 per 100,000 children.
  • Ischemic and hemorrhagic strokes are equally common.
  • Consensus guidelines exist for ischemic stroke but not hemorrhagic stroke in children.

Conclusions:

  • Pediatric stroke requires increased awareness among physicians and families.
  • Urgent, comprehensive evaluation is necessary to identify multiple risk factors.
  • Treatment involves supportive care and targeted therapies based on stroke cause and patient factors.

Related Concept Videos

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Stroke: Introduction and Types

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Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke l: Introduction01:15

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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.