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Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
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On the other...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Other Disorders of Digestive System

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Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

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Related Experiment Video

Updated: Jun 28, 2026

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
06:34

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

[Food-cobalamin syndrome].

Khalid Serraj1, Thomas Vogel, Laure Federici

  • 1Service de médecine interne, diabète et maladies métaboliques, Clinique médicale B, Hôpitaux universitaires de Strasbourg, F-67091 Strasbourg, France.

Presse Medicale (Paris, France : 1983)
|November 8, 2008
PubMed
Summary

Food-cobalamin malabsorption is a leading cause of vitamin B12 deficiency in adults, particularly the elderly. Diagnosis requires a specific strategy, with treatment involving oral cobalamin.

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The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
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Area of Science:

  • Gastroenterology and Hematology
  • Nutritional Science
  • Clinical Medicine

Context:

  • Food-cobalamin malabsorption is a recognized syndrome contributing significantly to cobalamin deficiency.
  • It is a primary cause of vitamin B12 deficiency in adults, especially the elderly, often associated with pernicious anemia.
  • Diagnosis is currently one of exclusion, necessitating a structured clinical approach.

Purpose:

  • To outline the diagnostic strategy for food-cobalamin malabsorption.
  • To identify the primary causes, including gastric disorders and medications like metformin and anti-acid drugs.
  • To review current treatment approaches and ongoing research into oral cobalamin therapy.

Summary:

  • Food-cobalamin malabsorption, a key cause of vitamin B12 deficiency in adults, requires a defined diagnostic pathway.
  • Gastric issues and certain medications (metformin, anti-acid drugs) are common etiologies.
  • Treatment involves lower-dose oral cobalamin compared to pernicious anemia, with ongoing studies validating its efficacy.

Impact:

  • Highlights the clinical significance of food-cobalamin malabsorption as a cause of vitamin B12 deficiency.
  • Emphasizes the need for a systematic diagnostic approach in affected patients.
  • Informs current and future therapeutic strategies, particularly regarding oral cobalamin supplementation.