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Published on: October 20, 2019
Can the classical euchromatic variants of 9q12/qh+ cause recurrent abortions?
M Dundar1, A O Caglayan, C Saatci
1Erciyes University, Medical Faculty, Department of Medical Genetics, Kayseri, Turkey. dundar@erciyes.edu.tr
Abstract:
Various heteromorphisms of the 9q heterochromatic area have been reported, and the 9q12/qh variant has been postulated to be more prevalent than initially perceived. Of note is that all probands are clinically normal. This paper documents two cases with a G-band within the 9q12h region and recurrent miscarriages. Patient 1 is a 22-year-old woman with a history of 2 miscarriages. Patient 2 is a 19-year-old woman with a history of 3 miscarriages. Chromosome analysis of the patients showed 46,XX,9q12h+. Thus, the existence of a G+ band in 9qh may not be a normal variant in humans. We suggest IVF and preimplantation genetic diagnosis in such patients.
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