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Published on: February 27, 2014
Do non-steroidal anti-inflammatory drugs increase colonic permeability?
A P Jenkins1, D R Trew, B J Crump
1Gastrointestinal Laboratory, St Thomas's Hospital, London.
This study used lactulose and 51Cr-EDTA to measure intestinal permeability. Results suggest non-steroidal anti-inflammatory drugs (NSAIDs) may increase permeability in the colon.
Area of Science:
- Gastroenterology
- Pharmacology
- Clinical Medicine
Background:
- Intestinal permeability is crucial for nutrient absorption and barrier function.
- Assessing permeability helps diagnose and understand gastrointestinal disorders.
- Non-steroidal anti-inflammatory drugs (NSAIDs) are known to affect the gastrointestinal tract.
Purpose of the Study:
- To evaluate intestinal permeability using dual sugar absorption markers.
- To investigate the effect of NSAIDs on small and large intestinal permeability.
- To differentiate between small and large intestinal permeability in healthy subjects and patients.
Main Methods:
- Oral administration of lactulose and 51 chromium-labelled ethylenediamine tetra-acetate (51Cr-EDTA) in healthy adults and ileostomy patients.
- Measurement of 24-hour urinary excretion of both markers.
- Simultaneous administration of markers to patients receiving NSAIDs for arthritis.
Main Results:
- In healthy subjects, 51Cr-EDTA recovery was higher than lactulose, suggesting differential absorption/metabolism.
- Ileostomy patients showed equal recovery of both markers.
- NSAID patients exhibited significantly increased 51Cr-EDTA recovery, particularly in later collections, indicating enhanced colonic permeability.
Conclusions:
- Lactulose and 51Cr-EDTA can differentiate small and large intestinal permeability.
- NSAIDs appear to increase colonic permeability, potentially contributing to gastrointestinal side effects.
- Further research is warranted to elucidate the mechanisms of NSAID-induced colonic permeability changes.
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