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Related Experiment Videos

Strontium toxicity in Drosophila melanogaster.

M W England1, J B Faust, E K Wilkerson

  • 1Health and Safety Research Division, Oak Ridge National Laboratory, Tennessee 37831-6123.

Toxicology
|January 1, 1991
PubMed
Summary

The gene(s) responsible for strontium resistance in Drosophila are located on the second chromosome. This finding builds upon previous research identifying the X-chromosome

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Area of Science:

  • * Genetics and toxicology in model organisms.
  • * Investigating heavy metal resistance mechanisms.

Background:

  • * Drosophila melanogaster strains exhibit varying resistance to toxic metals like cadmium chloride (CdCl2).
  • * Previous studies localized cadmium resistance genes to the X-chromosome.

Purpose of the Study:

  • * To determine the chromosomal location of gene(s) conferring strontium resistance in Drosophila.
  • * To compare the genetic basis of resistance to different heavy metals.

Main Methods:

  • * Utilized six specific Drosophila genotypes, representing combinations of major chromosomes from resistant (v;bw) and sensitive (Austin) strains.
  • * Assessed strontium resistance by measuring lethal concentration 50 (LC50) values.

Main Results:

  • * The gene(s) responsible for strontium resistance were mapped to the second chromosome.
  • * This contrasts with the previously identified X-chromosome location for cadmium resistance.

Conclusions:

  • * Strontium resistance in Drosophila is primarily controlled by genes on the second chromosome.
  • * Different heavy metals may be subject to distinct genetic control mechanisms for resistance in Drosophila.

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