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Strontium toxicity in Drosophila melanogaster
M W England1, J B Faust, E K Wilkerson
1Health and Safety Research Division, Oak Ridge National Laboratory, Tennessee 37831-6123.
Toxicology
|January 1, 1991
Summary
The gene(s) responsible for strontium resistance in Drosophila are located on the second chromosome. This finding builds upon previous research identifying the X-chromosome
Area of Science:
- * Genetics and toxicology in model organisms.
- * Investigating heavy metal resistance mechanisms.
Background:
- * Drosophila melanogaster strains exhibit varying resistance to toxic metals like cadmium chloride (CdCl2).
- * Previous studies localized cadmium resistance genes to the X-chromosome.
Purpose of the Study:
- * To determine the chromosomal location of gene(s) conferring strontium resistance in Drosophila.
- * To compare the genetic basis of resistance to different heavy metals.
Main Methods:
- * Utilized six specific Drosophila genotypes, representing combinations of major chromosomes from resistant (v;bw) and sensitive (Austin) strains.
- * Assessed strontium resistance by measuring lethal concentration 50 (LC50) values.
Main Results:
- * The gene(s) responsible for strontium resistance were mapped to the second chromosome.
- * This contrasts with the previously identified X-chromosome location for cadmium resistance.
Conclusions:
- * Strontium resistance in Drosophila is primarily controlled by genes on the second chromosome.
- * Different heavy metals may be subject to distinct genetic control mechanisms for resistance in Drosophila.