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Updated: Jun 28, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
An unusual variant of Cushing syndrome
Hosahithlu K Ganesh1, Joe George, Mavila V Vimal
1Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Objective:
To discuss the initial clinical manifestations of primary pigmented nodular adrenocortical disease.
Methods:
We present a case report of a 4-year-old boy who had the classic clinical features of Cushing syndrome. Results of hormonal investigations are reviewed, and histopathologic findings are illustrated.
Results:
Investigations revealed adrenocorticotropic hormone (corticotropin)-independent Cushing syndrome. Findings on magnetic resonance imaging of the pituitary gland and abdomen were within normal limits. The patient underwent bilateral adrenalectomy. The histopathologic features were consistent with primary pigmented nodular adrenocortical disease.
Conclusion:
Primary pigmented nodular adrenocortical disease should be suspected in patients with corticotropin-independent Cushing syndrome who have normal findings on adrenal imaging.
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