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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
The Rat Genome Database 2009: variation, ontologies and pathways
Melinda R Dwinell1, Elizabeth A Worthey, Mary Shimoyama
1Department of Physiology and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA. mrdwinel@mcw.edu
Nucleic Acids Research
|November 11, 2008
Summary
The Rat Genome Database (RGD) offers integrated genetic, genomic, and disease data for rat research. It provides tools and resources to advance the rat as a translational model for human diseases.
Area of Science:
- Genomics
- Bioinformatics
- Translational Medicine
Background:
- The Rat Genome Database (RGD) serves as a central resource for researchers studying the rat.
- It integrates diverse data types including genetic, genomic, pathway, phenotype, and strain information.
- The database focuses on data relevant to understanding disease.
Purpose of the Study:
- To provide researchers with comprehensive and accessible rat data.
- To enhance the utility of the rat as a translational model for human disease research.
- To develop and improve tools for data access and analysis.
Main Methods:
- Curating and integrating data from molecular to whole-organism levels.
- Developing and maintaining data access tools such as genome viewers and pathway diagrams.
- Creating disease-specific portals for integrated data analysis.
- Providing user education through tutorials and documentation.
Main Results:
- RGD offers structured, curated data on rat genetics, genomics, and phenotypes.
- Enhanced tools facilitate efficient data access in various formats.
- Disease Portals enable focused pathophysiological analysis.
- User education resources promote effective utilization of RGD.
Conclusions:
- RGD is a vital resource for leveraging rat research data.
- The database supports the rat's role as a translational model.
- Continuous development ensures RGD remains a valuable asset for investigators.
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