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Updated: Jun 28, 2026

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Risk reducing mastectomy: outcomes in 10 European centres.

D G R Evans1, A D Baildam, E Anderson

  • 1Central Manchester and Manchester Children's University Hospitals NHS Trust, St Mary's Hospital, Manchester, M13 0JH, UK. gareth.evans@cmmc.nhs.uk

Journal of Medical Genetics
|November 11, 2008
PubMed
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This summary is machine-generated.

Risk reducing mastectomy is highly effective for women at high risk of breast cancer, including BRCA1/2 carriers and non-carriers. This surgery significantly reduces cancer incidence, with no cases observed in the study cohort.

Area of Science:

  • Oncology
  • Genetics
  • Surgical Oncology

Background:

  • Growing number of high-risk women choose risk-reducing surgery for breast cancer prevention.
  • BRCA1/2 gene mutations significantly elevate breast cancer risk.

Purpose of the Study:

  • To evaluate the effectiveness of risk-reducing surgery in high-risk women.
  • To compare outcomes in BRCA1/2 carriers and non-carriers.

Main Methods:

  • Prospective data collection from 10 European centers since 1995.
  • Inclusion of women undergoing risk-reducing mastectomy and a control group.
  • Estimation of breast cancer risks using life tables.

Main Results:

  • 550 women underwent risk-reducing mastectomy with over 3334 woman-years of follow-up.

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  • No breast cancers occurred in the study cohort, whereas over 34 were expected.
  • A 2-3.6% rate of occult breast disease was detected during surgery.

    • Conclusions:

    • Risk-reducing surgery demonstrates high effectiveness in preventing breast cancer.
    • The procedure is a valuable option for high-risk women, including BRCA1/2 carriers and non-carriers.