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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Voxel-based morphometric multisite collaborative study on schizophrenia.

Judith M Segall1, Jessica A Turner, Theo G M van Erp

  • 1The Mind Research Network, Albuquerque, NM 87131, USA.

Schizophrenia Bulletin
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Pooling brain imaging data from multiple sites reveals consistent gray matter deficits in schizophrenia patients across various regions. This supports using combined data for more powerful analyses in schizophrenia research.

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Radiology

Background:

  • Regional gray matter (GM) abnormalities are characteristic of chronic schizophrenia.
  • Voxel-based morphometry (VBM) on structural MRI data has been used to identify these abnormalities.

Purpose of the Study:

  • To evaluate the consistency of GM concentration (GMC) differences between schizophrenia patients and controls across multiple study sites.
  • To assess the effects of pooling structural imaging data from two large multisite studies (fBIRN and MCIC) to increase statistical power.

Main Methods:

  • Voxel-based morphometry (VBM) analysis was performed on pooled structural MRI data from 503 subjects (266 controls, 237 patients).
  • Analyses were conducted on the combined sample and separately for each of the two multisite studies.
  • Region of interest analysis was used to evaluate imaging center-specific effects.

Main Results:

  • A consistent pattern of reduced relative GMC in schizophrenia patients compared to controls was observed across all nine study sites.
  • Combining data from the two multisite studies yielded a large sample, enhancing the ability to detect subtle effects.
  • Supporting evidence for GM deficits in temporal, anterior cingulate, and frontal regions in schizophrenia spectrum disorders was found.

Conclusions:

  • The findings support the utility of VBM in combined multisite studies for schizophrenia research.
  • Pooling data across imaging centers can increase statistical power to detect significant findings.
  • Consistent GM deficits in specific brain regions are further substantiated in schizophrenia spectrum disorders.