[Regulatory mechanims of smooth muscles contractility in the cerebral arteries]

The results obtained in the experiments on large cerebral arteries are summarized in the presented article. It was declared that direct application of these data to the properties and peculiarities of contractile activity having place in smooth muscles of the small arteries is not fully admissible, because these vessels have different spatial organization and rheological properties. More over, in accordance with the functional heterogeneity conception, such an application is not generally acceptable even from the theoretical point of view. This conception imply the specific analysis of neurohumoral signals effectiveness in every section of vascular bed, revival of electro- and chemo-excitable calcium channels peculiarities and taking into consideration features of innervations and spatial orientation of smooth muscle fibers in the vascular wall. It must be underlined, that on the level of small cortical arteries studies devoted to mentioned questions are not yet described in the literature.