RADON HORMESIS IN EPILEPTIC PATHOGENESIS AND PREDICTORS OF OXIDATIVE STRESS

Numerous experimental and clinical studies have shown that oxidative stress (OS) plays an important role in the development of epilepsy. The epileptic seizures themselves are caused by OS and, under conditions of a hypermetabolic state, cause an intensive production of reactive oxygen species (ROS) in the brain. The reason for this is called a change in the energy balance in the brain. According to the literature, ROS and other markers of oxidative stress were observed in the brain after seizures. Based on the above data, the aim of our study was to study a short-term 5-day (5 min) inhalation of radonized water from Tskhaltubo using an epileptic model of the Krushinsky-Molotkin line in rats and to identify changes in markers of oxidative stress in rats. Predictors of oxidative stress were studied, PAT, D-ROM (reactive oxygen metabolite index), OBRI (oxidative stress balance risk index) and OSI (oxidative stress index) were evaluated to assess the antioxidant capacity of plasma. Based on the data obtained, it can be concluded that: inhalation of Tskhaltubinsk water develops the effect of hormesis, which causes positive changes in all of the above markers of oxidative stress in the brain. Based on the data presented, inhalation of Tskhaltubo water can be considered as one of the methods for removing and treating convulsive phenomena, which is confirmed by experimental studies.