COMPARATIVE ANALYSIS OF MEMORY AND BEHAVIORAL CHANGES AFTER RADON-CONTAINED MINERAL WATER INHALATION THERAPY IN AGED...

Area of Science:

• Radiopharmacy
• Neuroscience
• Gerontology

Background:

• Age-related neurocognitive decline presents a significant health challenge.
• Radiopharmacy offers potential therapeutic avenues for managing age-related symptoms.
• Low-dose radiation, such as radon, is being explored for its health benefits.

Purpose of the Study:

• To investigate the therapeutic efficacy of low-dose radon inhalation on age-related neurocognitive processes.
• To evaluate the impact of radon on cognitive function and cellular markers of aging in an animal model.

Main Methods:

• An animal model was used to study the effects of radon inhalation via randomized mineral water.
• Cognitive function was assessed using Barnes maze tests.
• Cellular changes were analyzed by measuring Na, K-ATPase activity, telomerase activity, and oxidative stress levels.

Main Results:

• Radon inhalation reduced amyloid plaque concentration in aged rats.
• A significant improvement in cognitive function was observed in aged rats following radon therapy.
• Cellular analysis indicated reduced age-related changes in synaptic membranes and oxidative stress.

Conclusions:

• Exposure to radon-containing mineral water improved spatial perception and cognitive functions in aged rats.
• Radon therapy demonstrated positive effects at both the neurocognitive and cellular levels.
• These findings suggest radon's potential as a therapeutic agent for age-related cognitive impairment.