RADON HORMESIS IN EPILEPTIC PATHOGENESIS AND PREDICTORS OF OXIDATIVE STRESS

Area of Science:

• Neuroscience
• Biochemistry
• Environmental Medicine

Background:

• Oxidative stress (OS) is a key factor in epilepsy development and seizure generation.
• Seizures intensify reactive oxygen species (ROS) production in the brain due to altered energy balance.
• Elevated ROS and OS markers are observed in the brain post-seizure.

Purpose of the Study:

• To investigate the effects of short-term radonized Tskaltubo water inhalation on oxidative stress markers.
• To evaluate Tskaltubo water's impact on an epilepsy model in Krushinsky-Molotkin rats.

Main Methods:

• Rats from the Krushinsky-Molotkin epileptic line were exposed to 5-minute daily inhalations of radonized Tskaltubo water for 5 days.
• Plasma antioxidant capacity was assessed using PAT, D-ROM (reactive oxygen metabolite index), OBRI (oxidative stress balance risk index), and OSI (oxidative stress index).

Main Results:

• Inhalation of Tskaltubo water induced a hormetic effect.
• Significant positive changes were observed in all evaluated oxidative stress markers.
• The treatment demonstrated enhanced antioxidant capacity in the plasma.

Conclusions:

• Radonized Tskaltubo water inhalation exhibits hormetic properties beneficial for oxidative stress.
• This therapy may offer a potential method for managing and treating convulsive phenomena associated with epilepsy.
• Experimental findings support Tskaltubo water's therapeutic potential in epilepsy treatment.