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Updated: Jun 28, 2026
09:03
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Synthesis and anti-angiogenic activity of cortistatin analogs
Yuuki Sato1, Hiroshi Kamiyama, Takeo Usui
1Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Bioscience, Biotechnology, and Biochemistry
|November 11, 2008
Abstract:
Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.
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