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Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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Molecular mechanisms regulating glucocorticoid sensitivity and resistance

Katherine L Gross1, Nick Z Lu, John A Cidlowski

  • 1Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.

Molecular and Cellular Endocrinology
|November 13, 2008
PubMed
Summary

Glucocorticoid resistance in cancer treatment can arise from glucocorticoid receptor isoforms. Understanding these isoforms is key to improving therapy effectiveness for hematological malignancies.

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