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Updated: Jun 28, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Going nuclear is again a winning (Wnt) strategy
1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA. weimin.zhong@yale.edu
Abstract:
In this issue of Developmental Cell, Lyu and colleagues (2008) report that cleavage of Ryk, a transmembrane Wnt receptor, and the nuclear translocation of its intracellular domain (ICD) are essential for neuronal differentiation during mouse cortical neurogenesis. Their findings point to the possibility that Ryk, an atypical receptor tyrosine kinase, directly regulates Wnt target gene expression.
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