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Relation between estrogen receptor and malignancy of thyroid cancer
1Department of Surgery, Hiroshima University School of Medicine.
Japanese Journal of Cancer Research : Gann
|January 1, 1991
Summary
Thyroid cancer dedifferentiation correlates with estrogen receptor (ER) levels. Well-differentiated cancers show high ER immunoreactivity, while anaplastic cancers exhibit minimal to no ER expression, indicating a significant relationship.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Estrogen receptors (ER) play a role in various cancers.
- The association between ER and thyroid cancer dedifferentiation requires further investigation.
Purpose of the Study:
- To examine the relationship between histological grade of thyroid cancer dedifferentiation and estrogen receptors (ER).
Main Methods:
- Immunohistochemical analysis of ER in thyroid cancer tissues.
- Evaluation of ER immunoreactivity in well-differentiated, poorly differentiated, and anaplastic thyroid cancers from postmenopausal females.
Main Results:
- All well-differentiated papillary cancers showed ER immunoreactivity.
- ER-immunoreactive cells decreased significantly with increasing thyroid cancer atypism (P < 0.001).
- Anaplastic cancers showed negative ER-IR cells in 83.3% of cases.
Conclusions:
- A significant inverse correlation exists between thyroid cancer dedifferentiation and ER expression.
- ER status may serve as a potential biomarker for thyroid cancer progression.