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Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

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Related Experiment Video

Updated: Jun 28, 2026

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Automated time-lapse microscopy and high-resolution tracking of cell migration.

Joseph S Fotos¹, Vivek P Patel, Norman J Karin

¹Department of Biological Sciences, University of Delaware, Wolf Hall, Newark, DE, 19716, USA.

|November 13, 2008

Summary

A new automated microscopy system precisely tracks cell motility, revealing unique dynamics in glioma and osteoblastic cells. This high-throughput method enhances cell migration analysis for drug-treated and transfected cells.

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Related Experiment Videos

Last Updated: Jun 28, 2026

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Live-cell Imaging of Migrating Cells Expressing Fluorescently-tagged Proteins in a Three-dimensional Matrix

Live-cell Imaging of Migrating Cells Expressing Fluorescently-tagged Proteins in a Three-dimensional Matrix

Published on: December 22, 2011

Area of Science:

Cell Biology
Microscopy
Biotechnology

Background:

Cell motility is crucial for biological processes like development and disease.
Conventional microscopy methods have limitations in capturing dynamic cell behavior.
Tracking cell migration requires high spatial and temporal resolution.

Purpose of the Study:

To introduce a novel, automated high-throughput time-lapse microscopy system.
To evaluate the system's performance in precisely tracking cell motility.
To demonstrate the system's capability in revealing previously indiscernible cell motility behaviors.

Main Methods:

Developed a fully automated high-throughput time-lapse microscopy system.
Collected data at minute intervals over hours to days from multiple areas of interest.
Utilized "scratch" or "wound healing" assays for quantitation of cell velocity and path length.
Applied fluorescent vital labeling methods (GFP, DiO, Qtracker) for time-lapse studies.

Main Results:

The system precisely tracked motility of glioma and osteoblastic cell lines.
Revealed unique motility dynamics in drug-treated and adhesion molecule-transfected cells.
Demonstrated reduced tumor cell migration velocities when seeded onto monolayers expressing ectopic adhesion molecules.

Conclusions:

The novel system offers a considerable improvement over current cell motility measurement methods.
High-throughput time-lapse analysis enhances the resolution and accuracy of cell motility assays.
This technology will promote the development of new cell motility assays.