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Updated: Jun 28, 2026
Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Restraint stress up-regulates expression of zinc transporter Zip14 mRNA in mouse liver
Takuya Ohashi1, Tohru Matsui, Moeko Chujo
1Laboratory of Biosignals and Response, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan.
Abstract:
The zinc concentration in the liver was significantly higher in mice at 12 h after the onset of restraint stress than that without stress. The IL-6 protein level in the serum was transiently elevated at 3 h after the onset of restraint stress, and the IL-6-responsive zinc transporter Zip14 mRNA in the liver was expressed markedly at 6 h. These results suggest that Zip14 plays a major role in the mechanism responsible for accumulation of zinc in the liver under restraint stress.
