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Four new biflavonoids from Selaginella uncinata and their anti-anoxic effect
Jun-Xia Zheng1, Nai-Li Wang, Hong-Wei Liu
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Abstract:
The 60% ethanolic extract of Selaginella uncinata (Desv.) Spring possessed potent anti-anoxic effect in the anoxic PC12 cell assay. A phytochemical study of its EtOAc-soluble part led to the isolation of four new and three known biflavonoids. Their structures were established on the basis of physico-chemical properties and spectroscopic analysis. The absolute configurations of the new compounds were determined with the aid of circular dichroism (CD) spectroscopy. Compounds 4 and 5 showed potent anti-anoxic effect in the anoxic PC12 cell assay.
