Related Experiment Video
Updated: Jun 28, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
Aicardi syndrome mimicking intrauterine hydrocephalus
Deivasumathy Muthugovindan1, Eric H Kossoff, Ai Sakonju
1Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. dmuthug2@jhmi.edu
Abstract:
Congenital enlargement of the cerebral ventricles is now commonly recognized in utero due to the availability of high resolution prenatal ultrasonography. It is important to distinguish between congenital hydrocephalus and ventricular enlargement due to malformations, infections or other destructive processes because these disorders can have markedly different prognoses. We report an infant diagnosed with Aicardi syndrome in the newborn period based on brain MRI and ophthalmological findings after she was referred for evaluation of hydrocephalus seen on fetal ultrasound. Aicardi syndrome most commonly comes to medical attention because of seizures later in infancy.
Related Concept Videos
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Cerebral Edema ll: Pathophysiology
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Increased Intracranial Pressure ll: Pathophysiology
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...