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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Inflammation01:38

Inflammation

Overview

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Related Experiment Video

Updated: Jun 28, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

A20: central gatekeeper in inflammation and immunity.

Beatrice Coornaert1, Isabelle Carpentier, Rudi Beyaert

  • 1Department of Molecular Biology, Ghent University.

The Journal of Biological Chemistry
|November 15, 2008
PubMed
Summary

The ubiquitin-editing protein A20 negatively regulates immune signaling by controlling NF-kappaB activation. Understanding A20

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Signaling

Background:

  • Immune system dysfunction is implicated in immune deficiency, autoimmune diseases, and cancer.
  • Intracellular immune signaling pathways require precise regulation.
  • Nuclear Factor kappa B (NF-kappaB) is a key transcription factor in immune signaling.

Purpose of the Study:

  • To elucidate the mechanism of action of A20.
  • To describe the role of A20 in regulating inflammation and immunity.

Main Methods:

  • Discussion of A20's function as a ubiquitin-editing enzyme.
  • Analysis of A20's role in negative feedback of NF-kappaB signaling.

Main Results:

  • A20 acts as an early NF-kappaB-responsive gene.

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Last Updated: Jun 28, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
06:43

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

  • A20 participates in the negative feedback loop of NF-kappaB signaling.

    • Conclusions:

    • A20 is crucial for controlling inflammation and immunity.
    • A20's ubiquitin-editing activity is central to its regulatory function in immune responses.