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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Case Studies01:22

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
Observational Studies01:11

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...

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Related Experiment Video

Updated: Jun 28, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Recruitment to multicentre trials--lessons from UKCTOCS: descriptive study.

Usha Menon1, Aleksandra Gentry-Maharaj, Andy Ryan

  • 1Gynaecological Oncology, UCL EGA Institute for Women's Health, London W1T 7DN. u.menon@ucl.ac.uk

BMJ (Clinical Research Ed.)
|November 15, 2008
PubMed
Summary

Successful recruitment for the UK Collaborative Trial of Ovarian Cancer Screening involved proactive management and central support. Key factors included dedicated staff, prompt problem-solving, and adaptable strategies for inviting over 200,000 women.

Related Experiment Videos

Last Updated: Jun 28, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Area of Science:

  • Oncology
  • Clinical Trials
  • Public Health

Background:

  • The UK Collaborative Trial of Ovarian Cancer Screening aimed to recruit over 200,000 women.
  • Large-scale randomized controlled trials require robust recruitment strategies.

Purpose of the Study:

  • To identify and describe the factors contributing to the successful recruitment of a large cohort for the UK Collaborative Trial of Ovarian Cancer Screening.
  • To analyze the recruitment process of one of the largest ovarian cancer screening trials.

Main Methods:

  • Descriptive study design.
  • Recruitment involved 13 NHS trusts in England, Wales, and Northern Ireland.
  • Target participants were postmenopausal women aged 50-74, with specific exclusion criteria.

Main Results:

  • Over 1.2 million women were invited, with 23.2% expressing interest and 73.6% of those attending for recruitment, resulting in 202,638 randomized women over 4.3 years.
  • Acceptance rates varied significantly (19%-33%) across trial centers.
  • Successful recruitment was facilitated by dedicated coordinating center staff, rapid problem resolution, flexible invitation volumes, and large ad hoc clinics.

Conclusions:

  • Effective trial management and planning are critical, demanding senior investigator involvement.
  • Continuous monitoring by a proactive management team, offering tailored solutions and central resources, is essential for successful recruitment.
  • Automation via web-based systems, information videos, and group discussions can further enhance recruitment in large multicenter trials.