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A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Cutaneous angiosarcoma in a patient with xeroderma pigmentosum
Raman Arora1, Alok Sharma, Ruchika Gupta
1Department of Pathology, All India Institute of Medical Sciences, New Delhi 110 029, India.
Abstract:
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder characterized by photosensitivity, cutaneous pigmentary changes, premature skin ageing and development of various cutaneous and internal malignancies at an early age as a result of a defect in nucleotide excision repair following ultraviolet light exposure. Cutaneous angiosarcomas are aggressive neoplasms that are rarely associated with XP. In this communication, we report the case of a 40-year-old male patient with XP who developed an angiosarcoma of the face and discuss the implications of this association in view of recent developments in this field.
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