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Updated: Jun 28, 2026
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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
Curative stereotactic body radiotherapy for liver malignancy.
Peter Gunvén1, Henric Blomgren, Ingmar Lax
1Radiumhemmet Department of Oncology, Karolinska University Hospital at Solna, Stockholm 17176, Sweden. peter.gunven@karolinska.se
Medical Oncology (Northwood, London, England)
|November 15, 2008
Summary
Precision irradiation in a stereotactic body frame offers long-term survival for liver malignancies. This non-invasive method shows promise for patients with tumors unsuitable for surgery, with mild side effects.
Area of Science:
- Oncology
- Radiotherapy
Background:
- Liver non-neuroendocrine malignancies pose treatment challenges.
- Surgical options are limited for some patients.
- Non-invasive treatment modalities are needed.
Purpose of the Study:
- To evaluate the efficacy of precision irradiation for liver non-neuroendocrine malignancies.
- To assess long-term survival and recurrence rates.
- To determine the safety and tolerability of the treatment.
Main Methods:
- Nine patients with 11 liver malignancies received precision irradiation.
- Doses ranged from 20 to 45 Gy, fractionated over 2-4 sessions.
- Treatment was delivered using a stereotactic body frame.
Main Results:
- All nine patients achieved long-term survival (5-14 years) without recurrence.
- Side effects, including pain and nausea, were mild, requiring no hospitalizations.
- Two secondary cancers near the irradiated area were resected for cure.
Conclusions:
- Precision irradiation is a potentially curative, non-invasive treatment for selected liver malignancies.
- The method is suitable for patients with tumors technically unsuited for other treatments or at high surgical risk.
- Further studies are needed to optimize radiation doses and confirm local control rates.
