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Updated: Jun 28, 2026

Visualization of the Interstitial Cells of Cajal (ICC) Network in Mice
Published on: July 27, 2011
Interstitial cells of Cajal in the gut--a gastroenterologist's point of view
Lucian M Negreanu1, Philippe Assor, Bogdan Mateescu
1Department of Hepato-Gastroenterology, Trousseau University Hospital Center, Tours, France. negreanu_99@yahoo.com
Abstract:
Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specific treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, infantile hypertrophic pyloric stenosis, chronic intestinal pseudo-obstruction and slow transit constipation. Moreover we discuss the role of the Cajal cells in the development of stromal tumors of the gastrointestinal tract.
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