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Related Experiment Videos

Acute ventilatory response to green coffee dust extract.

E Zuskin1, B Kanceljak, T J Witek

  • 1Andrija Stampar School of Public Health, Zagreb, Yugoslavia.

Annals of Allergy
|March 11, 1991
PubMed
Summary
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Inhaling green coffee extract causes significant lung function decline in healthy individuals. This bronchoconstriction effect in response to coffee was not prevented by disodium cromoglycate (DSCG) pretreatment.

Area of Science:

  • Pulmonary Medicine
  • Allergy and Immunology

Background:

  • Green coffee extract can trigger airway hyperresponsiveness in some individuals.
  • The effects of green coffee inhalation on lung function, especially post-exercise, require further investigation.

Purpose of the Study:

  • To assess the impact of green coffee extract inhalation on lung function in healthy subjects with pre-existing airway hyperresponsiveness.
  • To evaluate the protective effect of disodium cromoglycate (DSCG) against coffee-induced bronchoconstriction.
  • To explore correlations between baseline airway hyperresponsiveness, skin prick test results, and lung function response to green coffee.

Main Methods:

  • Ten healthy subjects with known airway hyperresponsiveness to green coffee extract were studied.
  • Lung function was measured at rest and after exercise, with and without DSCG pretreatment.

Related Experiment Videos

  • Bronchial challenge tests included methacholine to assess baseline airway responsiveness.

    • Main Results:

    • Inhalation of green coffee extract caused a statistically significant decrease in lung function (P < .001) both at rest and post-exercise.
    • Disodium cromoglycate (DSCG) pretreatment did not provide significant protection against coffee-induced lung function decrements.
    • No correlation was found between baseline methacholine responsiveness or skin prick test results and the degree of lung function impairment following coffee exposure.

    Conclusions:

    • Green coffee extract inhalation induces significant bronchoconstriction in susceptible healthy volunteers.
    • Disodium cromoglycate is ineffective in preventing this coffee-induced airway narrowing.
    • The study highlights the potential for inhaled allergens like green coffee to trigger respiratory symptoms in sensitive individuals.