Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Breathing bad: increased risk for obstructive sleep apnea in current and former smokers.

Scientific reports·2026
Same author

Sex differences in obstructive sleep apnea: a population-based study from northeastern Germany.

Sleep & breathing = Schlaf & Atmung·2026
Same author

Clinical Outcomes and Long-Term Survival in Patients Undergoing Prolonged Weaning.

Respiration; international review of thoracic diseases·2025
Same author

Preserved Ratio Impaired Spirometry (PRISm) from an Epidemiological Perspective.

Journal of clinical medicine·2025
Same author

Exertional inspiratory capacity and operating lung volumes in health: a population-based study.

ERJ open research·2025
Same author

High Oscillometry-derived Airway Resistance Is Associated with FEV<sub>1</sub> Decline and Future Abnormal Spirometry in Smokers with Initially Normal Spirometry.

American journal of respiratory and critical care medicine·2025
Same journal

Impactful trials on dyslipidaemias, fractional flow reserve, beta-blockers, and peripheral artery disease.

European heart journal·2026
Same journal

Correction to: The Safe Hearts Plan for Europe and beyond.

European heart journal·2026
Same journal

AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026).

European heart journal·2026
Same journal

Unrepaired persistent truncus arteriosus in adulthood: a rare survival explained by anatomy and flow.

European heart journal·2026
Same journal

Biomarkers in cancer thrombosis: from association to mechanism and integrated risk.

European heart journal·2026
Same journal

Weight loss, exercise haemodynamics, and health status with incretin therapy for heart failure with preserved ejection fraction and obesity.

European heart journal·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Are serum thyrotropin levels within the reference range associated with endothelial function?

Henry Völzke1, Daniel M Robinson, Thomas Spielhagen

  • 1Institut für Community Medicine, Ernst-Moritz-Arndt-Universität, Walther Rathenau Str. 48, D-17487 Greifswald, Germany.

European Heart Journal
|November 18, 2008
PubMed
Summary
This summary is machine-generated.

High normal thyroid-stimulating hormone (TSH) levels are linked to poorer endothelial function, a marker of cardiovascular health. This suggests current TSH reference ranges may need reevaluation.

More Related Videos

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

Related Experiment Videos

Last Updated: Jun 28, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

Area of Science:

  • Endocrinology
  • Cardiovascular Research
  • Vascular Biology

Background:

  • Elevated serum thyrotropin (TSH) levels within the normal range may correlate with increased cardiovascular risk.
  • Endothelial dysfunction, a precursor to cardiovascular disease, is a key area of research.

Purpose of the Study:

  • To investigate the association between serum TSH levels and flow-mediated dilation (FMD) as a measure of endothelial function.
  • To explore if TSH levels within the reference range impact vascular health.

Main Methods:

  • Analysis of 1364 subjects from the Study of Health in Pomerania with serum TSH levels between 0.25 and 2.12 mIU/L.
  • Measurement of flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD) using standardized ultrasound techniques.
  • Statistical adjustments for age, sex, smoking, and blood pressure.

Main Results:

  • A trend of inverse association between serum TSH levels and FMD was observed (P = 0.130).
  • Subjects in the highest TSH quartile exhibited lower median FMD compared to the lowest quartile (P < 0.05).
  • Higher TSH levels were associated with increased odds of decreased FMD (OR 1.42, P < 0.05), particularly in men.

Conclusions:

  • Serum TSH levels within the upper reference range are associated with impaired endothelial function.
  • Findings suggest a potential need to reconsider the upper limit of the TSH reference range.