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Published on: July 19, 2018

Gastrointestinal hemorrhage in hemodialysis patients

J D Furkert1, M Zeier, V Schwenger

  • 1Nephrology and Gastroenterology, SLK-Kliniken Heilbronn, Bad Friedrichshall. juergen.furkert@slk-kliniken.de

Zeitschrift Fur Gastroenterologie
|November 18, 2008
PubMed

Insights

Gastrointestinal bleeding is more common in hemodialysis patients, with anticoagulants increasing this risk significantly. Careful consideration of medication benefits versus bleeding risks is crucial for these patients.

Area of Science:

  • Nephrology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Gastrointestinal bleeding is a serious complication.
  • Limited data exists on GI bleeding incidence in chronic hemodialysis patients.
  • This study aimed to determine GI bleeding frequency in a dialysis center.

Purpose of the Study:

  • To investigate the incidence of gastrointestinal bleeding in patients undergoing chronic hemodialysis.
  • To assess the impact of anticoagulant therapy on GI bleeding risk in this population.

Main Methods:

  • Retrospective data collection from 65 hemodialysis patients over a 7-year period (Jan 2000 - Feb 2007).
  • Analysis of all gastrointestinal bleeding episodes.
  • Comparison of bleeding risk between patients on anticoagulation and those not.

Main Results:

  • 11 gastrointestinal bleeding events occurred over 3195 patient-months of treatment.
  • Patients on anticoagulation had approximately a 3-fold higher risk of GI bleeding.
  • Bleeding occurred once every 16 years in anticoagulated patients vs. once every 46.2 years in non-anticoagulated patients.

Conclusions:

  • Hemodialysis patients exhibit an increased incidence of gastrointestinal bleeding compared to the general population.
  • Anticoagulant therapy further elevates the risk of GI bleeding in hemodialysis patients.
  • Clinical decisions regarding anticoagulation must balance therapeutic benefits against the heightened risk of gastrointestinal bleeding.
Abstract

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