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Microarray-based DNA methylation analysis of imprinted loci in a patient with transient neonatal diabetes mellitus

Jose I Martin-Subero1, Marina Bibikova, Deborah Mackay

  • 1Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, Christian-Albrechts University, Kiel, Germany.

American Journal of Medical Genetics. Part A
|November 18, 2008
PubMed
Abstract

No abstract available in PubMed .

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...