Amoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis
J P Nadler1, J Berger, J A Nord
1Department of Medicine, State University of New York Health Science Center, Brookdale Hospital, Brooklyn.
Abstract:
This report describes two patients with multidrug resistant tuberculosis who were successfully treated with the addition of amoxicillin-clavulanic acid to second-line drugs. Mycobacterium tuberculosis possesses a beta-lactamase contributing to its resistance to beta-lactam antibiotics. The combination of clavulanic acid, a beta-lactamase inhibitor, and amoxicillin has been shown bactericidal for M tuberculosis in vitro. These data suggest that resistant tuberculosis may warrant a trial of treatment including amoxicillin-clavulanic acid.
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