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Comment on administration and scoring of the Neuropsychiatric Inventory in clinical trials
Donald J Connor1, Marwan N Sabbagh, Jeffery L Cummings
1Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ, USA. donald.connor@bannerhealth.org
Background:
The Neuropsychiatric Inventory (NPI) is commonly used in dementia trials to quantify and qualitate changes in psychiatric symptoms.
Methods:
A questionnaire was administered to clinical trial raters to assess whether they were being trained to administer and score the NPI differently between clinical trial protocols.
Results:
Responses to the survey indicated that there are differences between clinical trials protocols in how the instrument is administered and scored.
Discussion:
Clarification of administration and scoring rules are provided, including the behavioral sampling period, whether premorbid characteristics are considered, and what behaviors are considered in rating frequency, severity, and caregiver distress.
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