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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
BioCapacitor--a novel category of biosensor
Takuya Hanashi1, Tomohiko Yamazaki, Wakako Tsugawa
1Department of Biotechnology, Graduate School of Engineering, Tokyo University of Agriculture & Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan.
Biosensors & Bioelectronics
|November 18, 2008
Summary
Researchers developed a novel BioCapacitor biosensor using a biocatalyst and capacitor to measure analytes. This self-powered enzyme sensor demonstrates effective glucose detection and wireless sensing capabilities.
Area of Science:
- Biosensor technology
- Biocatalysis
- Electrochemical sensing
Background:
- Biosensors integrate biological recognition elements with transducers for analyte detection.
- Capacitors can function as transducers in biosensing applications.
- Developing self-powered biosensors is crucial for portable diagnostic devices.
Purpose of the Study:
- To develop an innovative biosensor, the BioCapacitor, combining biological recognition with capacitive transduction.
- To establish a glucose measurement method using the BioCapacitor.
- To demonstrate a wireless sensing system utilizing the BioCapacitor.
Main Methods:
- Constructed a BioCapacitor using FAD-dependent glucose dehydrogenase (FADGDH) as the anodic catalyst.
- Utilized a charge pump circuit to charge the capacitor based on biocatalytic reaction rates.
- Monitored charge/discharge frequency for analyte concentration determination.
- Integrated the BioCapacitor with an infrared light emitting diode (IRLED) and phototransistor for wireless sensing.
Main Results:
- The BioCapacitor's charge/discharge frequency showed a positive correlation with glucose concentration.
- Demonstrated successful glucose measurement using the FADGDH-based BioCapacitor.
- Successfully implemented a wireless sensing system capable of detecting glucose presence via IR signal transmission.
Conclusions:
- The BioCapacitor functions as a self-powered enzyme sensor.
- The developed biosensor offers a promising platform for analyte detection.
- The wireless sensing capability enhances the potential for remote monitoring applications.
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