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Updated: Jun 27, 2026

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Published on: May 15, 2015
Increasing speed of enantiomeric separations using supercritical fluid chromatography
1Merck & Co., Inc., Rahway, New Jersey, USA.
Abstract:
Enantioselective separation by supercritical fluid chromatography (SFC) has been a field of great progress since the first demonstration of a chiral separation by SFC in the 1980s. The unique properties of supercritical fluids make packed column SFC the most favorable choice for fast enantiomeric separation among all of the separation techniques. In this chapter, the effect of chiral stationary phases, modifiers, and additives on enantioseparation are discussed in terms of speed and resolution in SFC. Fundamental considerations and thermodynamic aspects are also presented.
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