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Updated: Jun 27, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Deproteinized bovine bone versus beta-tricalcium phosphate in sinus augmentation surgery: a comparative histologic
Antonin Simunek1, Dana Kopecka, Rakesh V Somanathan
1Department of Dentistry, Charles University in Prague, Faculty of Medicine, Hradec Kralove, Czech Republic. simunek@email.cz
Purpose:
To compare the efficacy of 2 common materials in sinus augmentation surgery and to assess their contribution when enriched with autogenous bone.
Materials And Methods:
The prospective human study was performed in 48 sinus grafting operations using beta-tricalcium phosphate or deproteinized bovine bone (pure or mixed with 10% to 20% autogenous bone) or autogenous bone. Biopsy specimens were taken after 9 months. Statistical evaluation was done with a 2-sample t test (P < .05).
Results:
When autogenous bone was used, 49.2% +/- 3.1% of new bone was found, which is significantly higher than in all the other groups. A higher proportion (34.2% +/- 13.1%) of the new vital bone was found in the deproteinized bovine bone group, in comparison with the beta-tricalcium phosphate group (21.4% +/- 8.1%) and the beta-tricalcium phosphate composite graft group (24.0% +/- 6.6%; P < .05). No significant differences between single-component grafts and corresponding composite grafts were established.
Conclusions:
Sinus augmentation with the aforementioned augmentation materials is a well-accepted procedure. However, autogenous bone alone was the best material. More new bone was found using deproteinized bovine bone than beta-tricalcium phosphate. The addition of 10% to 20% autogenous bone to the bone substitute did not significantly influence the new bone formation.
