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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Related Experiment Video

Updated: Jun 27, 2026

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
08:30

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder

Published on: September 6, 2024

AutDB: a gene reference resource for autism research.

Saumyendra N Basu1, Ravi Kollu, Sharmila Banerjee-Basu

  • 1MindSpec Inc., 9656 Blake Lane, Fairfax, VA 22031, USA.

Nucleic Acids Research
|November 19, 2008
PubMed
Summary
This summary is machine-generated.

AutDB is a new web portal that collects and annotates genes linked to Autism Spectrum Disorders (ASD). This resource aids researchers in understanding the genetic complexity of ASD and its underlying molecular mechanisms.

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Strategies for Assessing Autistic-Like Behaviors in Mice
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Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
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Area of Science:

  • Genetics
  • Bioinformatics
  • Neuroscience

Background:

  • Autism Spectrum Disorders (ASD) present significant genetic complexity with numerous candidate genes identified.
  • Existing resources may not fully capture the breadth of genetic information relevant to ASD.

Purpose of the Study:

  • To develop AutDB, a comprehensive, publicly available web portal for collecting, annotating, and visualizing genes associated with ASD.
  • To provide a curated, up-to-date reference dataset for ASD candidate genes to facilitate research into molecular mechanisms.

Main Methods:

  • Developed a disease-driven database model for AutDB.
  • Collected and manually annotated genes linked to ASD from published scientific literature.
  • Classified genes based on genetic variation: association studies, rare mutations, and syndromic autism.

Main Results:

  • AutDB provides a centralized, annotated repository of ASD-related genes.
  • Gene entries include detailed information on molecular functions and relevance to autism.
  • The database categorizes genes based on different types of genetic evidence.

Conclusions:

  • AutDB serves as a valuable, up-to-date resource for the research community studying ASD genetics.
  • The database model can be adapted for other genetically complex disorders.
  • Facilitates the interrogation of molecular mechanisms underlying ASD through consolidated genetic knowledge.