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DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
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Published on: March 15, 2011

Selection of oligonucleotides for whole-genome microarrays with semi-automatic update

G Golfier1, S Lemoine, A van Miltenberg

  • 1Neurobiologie et Diversité Cellulaire, CNRS UMR7637, Ecole Supérieure de Physique et de Chimie Industrielles, 10 rue Vauquelin, 75005 Paris, France.

Bioinformatics (Oxford, England)
|November 19, 2008
PubMed
Abstract

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...