Related Experiment Video
Updated: Jun 27, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
Published on: August 22, 2016
A three-layer model of skin and its application in simulating wrinkling
Cormac O Flynn1, Brendan A O McCormack
1School of Engineering, Institute of Technology, Sligo, Ireland. flynn.cormac@itsligo.ie
Abstract:
Human skin is a complex multi-layer material. Many existing numerical skin models accurately simulate several of its complex mechanical characteristics. However, few models simulate wrinkling - a phenomenon common to all human skin. In this study, a multi-layer model of skin was developed to simulate wrinkling. The model consisted of the stratum corneum, dermis and underlying hypodermis. The results of the simulations were compared with results of in vivo wrinkling experiments performed on the volar forearm. The proposed three-layer skin model simulates wrinkling more realistically than models of fewer layers. The size of the wrinkles predicted by the model fell within the range of the wrinkle sizes measured in the experiments. The maximum range and average roughness differed by 34 and 43% from the corresponding mean experimental results, respectively. Applications of the model include simulating skin aging, designing more realistic artificial skin and the development of surgical simulators.
Related Concept Videos
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Layers of the Epidermis
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
Renewal of Skin Epidermal Stem Cells
Cells of the Epidermis
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

