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Related Experiment Video

Updated: Jun 27, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

[Traumatic Endophthalmitis Prevention Trial (TEPT)].

A Viestenz¹, W Schrader, W Behrens-Baumann

¹Univ.-Augenklinik, Otto-von-Guericke-Universität, Magdeburg. dr.arne.viestenz@t-online.de

Klinische Monatsblatter Fur Augenheilkunde

|November 19, 2008

Summary

This summary is machine-generated.

This study investigates if adding an intravitreal antibiotic injection to intravenous antibiotics can prevent post-traumatic endophthalmitis after severe eye injuries. Results will compare infection rates between treatment groups.

Related Experiment Videos

Last Updated: Jun 27, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Area of Science:

Ophthalmology
Infectious Diseases
Trauma Surgery

Background:

Post-traumatic endophthalmitis is a severe complication of open globe injuries, occurring in 2-17% of cases.
Early intravenous antibiotics are crucial for minimizing this risk.
The efficacy of additional intravitreal antibiotics in prevention remains to be fully elucidated.

Purpose of the Study:

To design and present a study evaluating the role of an additional intravitreal antibiotic injection in preventing post-traumatic endophthalmitis.
To compare the effectiveness of intravenous antibiotics alone versus combined intravenous and intravitreal antibiotics.

Main Methods:

A prospective, multicentre, randomised controlled study design.
Inclusion of patients with penetrating or perforating eye injuries treated within 24 hours.
Randomization into two groups: intravenous moxifloxacin alone, or intravenous moxifloxacin plus intravitreal Vancomycin and Ceftazidim.

Main Results:

Seventeen European Ophthalmology Departments are participating.
Statistical comparison of post-traumatic endophthalmitis rates between the two treatment arms.
A 6-month follow-up period is planned for all participants.

Conclusions:

The study aims to provide evidence-based recommendations for the prevention of post-traumatic endophthalmitis.
Further participation in the TEPT study is encouraged from other ophthalmology departments.