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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

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Published on: September 20, 2024

Relapsing polychondritis and airway involvement.

Armin Ernst¹, Samaan Rafeq¹, Phillip Boiselle²

¹Department of Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA.

|November 20, 2008

Summary

This summary is machine-generated.

Symptomatic airway involvement is common in relapsing polychondritis (RP), affecting 21% of patients. Interventions for diverse airway issues like malacia and stenosis often lead to symptom improvement.

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Published on: September 20, 2024

Area of Science:

Rheumatology
Pulmonology
Otolaryngology

Background:

Relapsing polychondritis (RP) is a rare, multisystem inflammatory disease.
Airway involvement is a serious complication of RP, but its prevalence and characteristics are not well-defined.

Purpose of the Study:

To determine the prevalence and specific characteristics of airway involvement in patients with relapsing polychondritis.
To analyze the types of airway pathologies and the effectiveness of interventions.

Main Methods:

Retrospective chart review of patients diagnosed with RP between January 2004 and February 2008.
Analysis of data from the Rheumatology Clinic and Complex Airway Center.

Main Results:

Twenty-one percent (31/145) of RP patients had airway involvement.
Tracheomalacia (48%) and subglottic stenosis (26%) were the most common airway issues.
Dyspnea was the most frequent symptom (64%); airway interventions were successful in 40% of patients.

Conclusions:

Symptomatic airway involvement in relapsing polychondritis is common and can be severe.
Tracheomalacia is the most frequent airway complication.
Interventions for airway problems in RP can significantly improve symptoms.