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Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
11C-Acetate PET imaging for renal cell carcinoma
Nobuyuki Oyama1, Hidehiko Okazawa, Naoya Kusukawa
1Department of Urology, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui 910-1193, Japan. urono@u-fukui.ac.jp
European Journal of Nuclear Medicine and Molecular Imaging
|November 20, 2008
Summary
Positron emission tomography (PET) with (11)C-acetate (AC) shows promise for detecting renal cell carcinoma. AC uptake was observed in 70% of renal cell carcinomas, aiding in cancer evaluation.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Renal cell carcinoma (RCC) is a significant health concern.
- Accurate diagnostic tools are crucial for effective RCC management.
- Positron emission tomography (PET) offers functional imaging capabilities.
Purpose of the Study:
- To evaluate the efficacy of (11)C-acetate (AC) PET for diagnosing renal cell carcinoma.
- To determine the tracer uptake patterns of AC in renal lesions.
- To compare AC PET findings with CT and histopathology.
Main Methods:
- Twenty patients with suspected renal tumors underwent whole-body PET imaging after AC administration.
- Renal lesions were scored based on AC uptake.
- PET results were correlated with CT scans and surgical histopathological diagnoses.
Main Results:
- AC PET identified 70% (14/20) of renal cell carcinomas.
- All complicated cysts (2) showed negative AC PET findings.
- A papillary renal cell carcinoma demonstrated high AC uptake.
Conclusions:
- (11)C-acetate (AC) exhibits significant uptake in renal cell carcinoma.
- AC PET is a potential imaging tracer for renal cancer detection.
- Further research is warranted to confirm AC PET's role in clinical practice.
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