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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Harnessing experience: exploring the gap between evidence-based medicine and clinical practice
M Cameron Hay1, Thomas S Weisner, Saskia Subramanian
1Department of Anthropology, Miami University, Oxford, OH, USA. mchay@ucla.edu
Physicians often bridge the gap between Evidence-based Medicine (EBM) and practice using clinical experience. Evidence Farming (EF) offers a systematic method to integrate this valuable experience, enhancing clinical decision-making and patient care.
Area of Science:
- Medical Practice and Clinical Decision-Making
- Health Services Research
Background:
- A recognized disparity exists between Evidence-based Medicine (EBM) and current physician practices.
- EBM often utilizes averaged global data, which may not align with local patient populations and circumstances.
- Local, real-world evidence is crucial for timely and relevant clinical decision-making.
Purpose of the Study:
- To explore physicians' perspectives on integrating clinical experience with EBM.
- To evaluate the potential of Evidence Farming (EF) in generating locally relevant evidence.
- To understand how physicians utilize various information sources in clinical decision-making.
Main Methods:
- A pilot study involving 29 individual interviews and three focus groups (n=10) with physicians.
- Exploration of physicians' current information-seeking behaviors and decision-making processes.
- Assessment of physicians' views on the concept and utility of Evidence Farming (EF).
Main Results:
- Physicians acknowledge the EBM-to-practice gap and frequently rely on clinical experience, colleague opinions, and electronic resources over direct EBM literature.
- Physicians' confidence in clinical experience grows with time, but systematic tracking of this experience is rare.
- The majority of physicians perceive Evidence Farming (EF) as a valuable tool for making scientific evidence more applicable to their practice.
Conclusions:
- Clinical experience, though vital, is underutilized within the EBM framework.
- Systematically collecting clinical experience through methods like Evidence Farming (EF) can address the limitations of current EBM approaches.
- EF has the potential to bridge the gap between EBM and practical clinical application by incorporating real-world physician insights.
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