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Scattering And Absorption of Light in Planetary Regoliths
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Published on: July 1, 2019

Quantification of scattering changes using polarization-sensitive optical coherence tomography.

Sang-Won Lee1, Jin-Ho Kang, Ji-Yeong Yoo

  • 1Yonsei University, Department of Biomedical Engineering, Wonju, South Korea.

Journal of Biomedical Optics
|November 22, 2008
PubMed
Summary
This summary is machine-generated.

Changes in light polarization measured by polarization-sensitive optical coherence tomography (PS-OCT) correlate linearly with scattering changes in tissues. This finding supports using the axial DOP slope for diagnosing tissue pathology.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Tissue Optics

Background:

  • The degree of polarization (DOP) is sensitive to scattering properties of biological tissues.
  • Optical coherence tomography (OCT) is a non-invasive imaging modality.
  • Polarization-sensitive OCT (PS-OCT) provides additional information about tissue microstructure.

Purpose of the Study:

  • To investigate the relationship between the degree of polarization (DOP) and scattering coefficient.
  • To demonstrate the utility of PS-OCT for quantifying scattering changes in phantoms.
  • To validate the use of axial DOP slope for tissue pathology diagnosis.

Main Methods:

  • Utilizing a polarization-sensitive optical coherence tomography (PS-OCT) system.
  • Employing liquid phantoms (Intralipid suspensions) and solid phantoms (gelatin).
  • Quantifying DOP changes with depth and correlating them with scattering coefficient variations.

Main Results:

  • A clear linear relationship was observed between DOP change and scattering change.
  • DOP changes with depth were successfully quantified in both liquid and solid phantoms.
  • The axial slope of DOP differed between normal and pathological cervical tissues in a prior study.

Conclusions:

  • The degree of polarization (DOP) is a reliable indicator of scattering coefficient changes.
  • PS-OCT can accurately quantify scattering variations in biological tissues.
  • Quantification of the axial DOP slope shows potential for systematic diagnosis of tissue pathology.