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Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry

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Accidental intoxication with Veratrum album.

T Grobosch¹, T Binscheck, F Martens

¹Berliner Betrieb für Zentrale Gesundheitliche Aufgaben (BBGes), Institute of Toxicology and Poison Information Centre Berlin, Oranienburger Str. 285, 13437 Berlin, Germany. grobosch.tox@bbges.de

Journal of Analytical Toxicology

|November 22, 2008

Summary

This summary is machine-generated.

A man experienced severe poisoning symptoms after consuming yellow gentian (Gentiana lutea) beverage. Analysis confirmed Veratrum alkaloids, specifically protoveratrines A and B, in the drink and patient

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Area of Science:

Toxicology
Analytical Chemistry
Pharmacology

Background:

Yellow gentian (Gentiana lutea) is traditionally used in herbal remedies.
Plant-derived toxins can cause severe adverse health effects.
Accurate identification and quantification of toxins are crucial for patient management.

Observation:

A patient presented with nausea, vomiting, bradycardia, and hypotension after ingesting a beverage containing yellow gentian.
Protoveratrines A and B were detected in the beverage and the patient's serum.
Symptoms resolved within 24 hours following medical treatment.

Findings:

The beverage contained 20.4 mg/L protoveratrine A (ProA) and 13.7 mg/L protoveratrine B (ProB).
Patient's serum concentrations were 1162 ng/L for ProA and 402 ng/L for ProB.
A validated liquid chromatography-tandem mass spectrometry (LC-MS-MS) method enabled rapid (6-min) simultaneous quantification of Veratrum alkaloids.

Implications:

This case highlights the potential toxicity of Gentiana lutea due to Veratrum alkaloid contamination.
The developed LC-MS-MS method is effective for rapid and accurate detection of Veratrum alkaloids in biological and food samples.
Clinical awareness and rapid analytical methods are essential for managing poisoning from herbal products.