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[Depressive and anxiety symptoms in hereditary connective tissue disorders : case description and systematic

M Vanwesemael, M Danckaerts, S Schevenels

    Tijdschrift Voor Psychiatrie
    |November 10, 2023
    PubMed

    Insights

    Individuals with hereditary connective tissue disorders like Loeys-Dietz syndrome often experience depression and anxiety. Pain, fatigue, and functional limitations appear to contribute to these mental health challenges.

    Area of Science:

    • Genetics and Rare Diseases
    • Psychiatry and Mental Health
    • Rheumatology and Connective Tissue Diseases

    Background:

    • Hereditary connective tissue disorders (HCTDs) are congenital conditions causing tissue weakness and multisystem issues.
    • Loeys-Dietz syndrome (LDS), Ehlers-Danlos syndrome (EDS), and Marfan syndrome (MFS) are examples of HCTDs.
    • A case of a 14-year-old with LDS presenting with depressive and anxiety symptoms prompted this investigation.

    Conclusions:

    • There is a notable link between hereditary connective tissue disorders and higher rates of depression and anxiety.
    • Pain, fatigue, social factors, and functional impairments are likely contributors to mental health issues in these patients.
    • Further research is needed to pinpoint specific contributing factors for targeted prevention and treatment strategies.

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