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Updated: Jun 27, 2026

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
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High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

FLASH: a rapid method for prototyping paper-based microfluidic devices.

Andres W Martinez1, Scott T Phillips, Benjamin J Wiley

  • 1Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Lab on a Chip
|November 22, 2008
PubMed
Summary
This summary is machine-generated.

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This study introduces Fast Lithographic Activation of Sheets (FLASH), a simple, rapid method for prototyping paper-based microfluidic devices. This technique enables low-cost diagnostics in resource-limited settings.

Area of Science:

  • Microfluidics
  • Materials Science
  • Biotechnology

Background:

  • Paper-based microfluidic devices offer low-cost, simple diagnostics for developing regions.
  • Conventional photolithography requires specialized facilities, limiting accessibility.

Purpose of the Study:

  • To present Fast Lithographic Activation of Sheets (FLASH) as a rapid prototyping method for paper microfluidics.
  • To enable microfluidic device fabrication without clean-room facilities.

Main Methods:

  • FLASH utilizes a UV lamp and hotplate for photolithography on paper.
  • Photomasks can be created using standard printers or hand-drawn designs.
  • The method is adaptable for use with sunlight in the absence of a UV lamp and hotplate.

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Last Updated: Jun 27, 2026

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Main Results:

  • FLASH achieves channel dimensions as small as 200 microm in width and 70 microm in height.
  • The technique successfully prototypes paper-based microfluidic devices.

Conclusions:

  • FLASH is a straightforward and accessible method for prototyping paper-based microfluidic devices.
  • This technology is particularly suitable for resource-limited environments and the developing world.