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Beyond Wax Printing: Fabrication of Paper-Based Microfluidic Devices Using a Thermal Transfer Printer.

Ryan A Ruiz1, Jorge L Gonzalez1, Miguel Vazquez-Alvarado1

  • 1Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, California 93407, United States.

Analytical Chemistry
|June 13, 2022
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Summary

A new thermal transfer printing method offers a low-cost, convenient alternative for fabricating paper-based microfluidic devices (microPADs). This accessible technique supports the advancement of point-of-care diagnostics.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Paper-based microfluidic devices (microPADs) are low-cost analytical tools for point-of-care diagnostics.
  • Fabrication typically involves patterning hydrophobic inks on paper to create hydrophilic channels.
  • Wax printing using solid ink printers was a popular, convenient fabrication method.

Purpose of the Study:

  • To introduce a new, accessible method for fabricating microPADs.
  • To provide an alternative to discontinued wax printing techniques.
  • To facilitate the continued development of paper-based microfluidics.

Main Methods:

  • Utilized a portable thermal transfer printer for microPAD fabrication.
  • Compared thermal transfer printed devices to those made by wax and laser printing.
  • Evaluated device performance and fabrication convenience.

Main Results:

  • Thermal transfer printing successfully fabricated functional microPADs.
  • Devices fabricated by thermal transfer printing were comparable to those made by wax and laser printing.
  • The method offers low cost, convenience, and portability.

Conclusions:

  • Thermal transfer printing is a viable and convenient alternative to wax printing for microPAD fabrication.
  • This approach can replace wax printing and support the growth of paper-based microfluidics.
  • The accessibility of this method can benefit researchers with limited resources.