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Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Primary Symptoms of COPD:

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Related Experiment Videos

Pulmonary diseases and corticosteroids.

G R Sethi1, Kamal Kumar Singhal

  • 1Department of Pediatrics Maulana Azad Medical College, New Delhi, India. grsethi56@gmail.com

Indian Journal of Pediatrics
|November 22, 2008
PubMed
Summary

Corticosteroids are effective anti-inflammatory drugs for many lung conditions like asthma, but their use is debated in others. Clinicians must balance benefits against side effects, especially with systemic steroids.

Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Corticosteroids are potent anti-inflammatory agents widely used in respiratory medicine.
  • Their efficacy is well-established in conditions such as asthma and croup, and for reducing respiratory distress syndrome.
  • However, their role is controversial in numerous other pulmonary diseases, often used empirically despite limited evidence.

Purpose of the Study:

  • To review the established and controversial roles of corticosteroids in various pulmonary conditions.
  • To highlight the benefits and risks associated with both systemic and inhaled corticosteroid use.
  • To emphasize the importance of evidence-based protocols and monitoring for adverse effects.

Main Methods:

  • Literature review of corticosteroid use in pulmonary diseases.

Related Experiment Videos

  • Analysis of established benefits versus controversial applications.
  • Discussion of systemic versus inhaled corticosteroid administration and their respective side effect profiles.

    • Main Results:

    • Corticosteroids demonstrate clear benefits in specific inflammatory lung diseases.
    • Empirical use is common in many conditions where evidence is lacking.
    • Both systemic and inhaled corticosteroids carry risks, including potential growth impairment with systemic use.

    Conclusions:

    • Corticosteroids are valuable in managing certain pulmonary inflammatory conditions.
    • Careful consideration of benefits versus risks, particularly side effects, is crucial for clinical decision-making.
    • Adherence to established protocols and vigilant monitoring for adverse effects are recommended.